Postdoctoral position is available immediately for highly motivated candidate to study the genetic etiology and developmental biology of human craniofacial anomalies with specific focus on craniosynostosis. The successful candidate will join the laboratory of Dr. Simeon Boyadjiev Boyd, medical geneticist and Dr. Jinoh Kim, cell biologist, at the Department of Pediatrics, Division of Genomic Medicine, University of California Davis. Specific projects in the lab include the identification of risk genes and loci through genome-wide association studies (GWAS), whole exome sequencing, candidate gene next generation sequencing, and in near future whole genome sequencing. Through an international collaborative project we have created clinical databases and sample repository of 1,300 affected families. We established strong associations to BMP2 and BBS9 in a cohort of patients with sagittal craniosynostosis (see Justice et al, Nat Genet v. 44, Dec. 2012) and are currently conducting cell culture and animal model based functional studies of these genes. We are in process of a GWAS of 400 case-parent trios with metopic craniosynostosis. In addition to genomic approaches, the project will employ state-of-the-art molecular and cellular biology approaches, including proteomics analysis, 3C, ChIP-seq, RNA-seq, DNA methyl-seq and other large-scale genetic and epigenomic analyses, and state-of-the-art gene manipulations using RNAi and CRISPR technology. A long-term goal of the lab is to identify the genetic and environmental cause of craniosynostosis, to identify biomarkers for this condition and to create animal models to be used for development of small molecule treatment strategies.
The candidates should have a PhD or equivalent degree in a biological science. Expertise in molecular genetics, cell and/or molecular biology and/or animal models is essential. Experience with computational statistical analysis of large scale genomic data sets is an advantage, but not essential. International applicants will be considered. Successful applicants will be able to learn the current approaches of analyses of multifactorial disorders using large datasets.
How to Apply
Interested candidates should send an email to Dr. Simeon Boyd (email@example.com) with:
- A summary of achievements
- Research interest
- Updated CV
- Information for 3 Letters of Reference
The University of California, Davis is an Equal Opportunity/Affirmative Action Employer with a strong institutional commitment to the achievement of diversity among its faculty and staff. Postdoctoral Fellows at UC Davis are represented by the UAW union.